高通量血液透析对维持性血液透析患者微炎症状态的影响

Changes of microinflammatory state in hemodialysis patients using high-flux membrane dialyzer

目的前瞻性研究高通量血液透析对患者微炎症状况的影响。方法前瞻性、自身对照研究。30例维持性常规低通量血液透析患者转换为高通量血液透析12个月。治疗0个月(治疗前)、6个月、12个月分别测定血中高敏C反应蛋白、白细胞介素1和白细胞介素6。结果转换为高通量透析12个月后,血清白细胞介素6水平明显下降(P<0.05),高敏感C反应蛋白和白细胞介素1水平较前无明显变化。结论长时间高通量血液透析不会加剧透析患者体内微炎症状态,而且可能对微炎症状态有一定改善作用。

Objective This is a prospective and self-controlled study designed to detect whether the microinflammatory state improves in hemodialysis patients using high-flux dialysis. Methods Thirty patients on maintenance low-flux hemodialysis were included in this study. They were then switched the dialyzer from low-flux dialyzer to high-flux F60 or FX60 dialyzer without changes of dialysis prescription. Serum high sensitivity C-reactive protein （hCRP）, interleukin-1 （IL-1）, interleukin-6 （IL-6） and albumin were determined after the switch for 0, 6 and 12 months. Results After the switch from low-flux hemodialysis to high-flux hemodialysis for 12 months, serum hCRP and IL-1 remained unchanged. Serum IL-6 was （39.97±41.03）ng/L, （36.81±37.09）ng/L and （15.17±1.54）ng/L （P0.05） after the switch for 0, 6 and 12 months, respectively. Conclusions Switch from low-flux hemodialysis to high-flux hemodialysis may ameliorate the microinflammatory state in maintenance hemodialysis patients.