期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

浅谈PIMT在阿尔兹海默病中作用机制 被引量：1

Discussion of the mechanism of PIMT in Alzheimer's disease
下载PDF
导出
摘要 阿尔兹海默病(AD)严重影响现代老年人生活质量,其治疗成为研究热点问题。蛋白L型异天冬氨酰基/D型天冬氨酰基邻甲基转移酶(PIMT)对AD中淀粉样β蛋白沉积起到抑制作用,其过程包括对异天冬氨酸的修复功能和对α分泌酶表达的调节,为AD治疗提供一个新的方向。 Alzheimer＇s disease seriously affectes the modem elderly people＇s life qualities so that it treating become a hot issue- Protein-L-isoaspartyl/D-aspartyl o-methyltransferase （PIMT） has a inhibit effect to Amyloid β Protein deposition in AD, this process contains repair function to different aspartate and regulate function to the expression of a secretase, provides a new direction to treating AD-
作者 李昊怡 韩雪 李晓智
机构地区 中国医科大学
出处 《中医临床研究》 2011年第9期108-109,共2页 Clinical Journal Of Chinese Medicine
关键词 阿尔兹海默病 淀粉样Β蛋白 PIMT 异天冬氨酸 α分泌酶 Alzheimer＇s disease Amyloid β protein PIMT Different aspartate a secretase
分类号 R246-6 [医药卫生—针灸推拿学]
  • 相关文献

参考文献1

二级参考文献27

  • 1Dodart JC, May P. Overview on rodent models of Alzheimer's disease. Curr Protoc Neurosci 2005; Chapter 9: Unit 9.22.
  • 2Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-6.
  • 3De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyroid precursor protein. Nature 1998; 391: 387-90.
  • 4Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon J J, et al. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the AIzheimer amyloid protein precursor. J Biol Chem 1998; 273: 27765-7.
  • 5Grillo MA, Colombatto S. S-adenosylmethionine and its products. Amino Acids 2008; 34: 187-93.
  • 6Kennedy BP, Bottiglieri T, Arning E, Ziegler MG, Hansen LA, Masliah E. Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function. J Neural Transm 2004; 111: 547-67.
  • 7Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, et al. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 2007; 27: 2751-9.
  • 8Bottiglieri T. S-AdenosyI-L-methionine (SAMe): from the bench to thebedside - molecular basis of a pleiotrophic molecule. Am J Clin Nutr 2002; 76: 1151S-7S.
  • 9Yamamoto A, Takagi H, Kitamura D, Tatsuoka H, Nakano H, Kawano H, et al. Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy. J Neurosci 1998; 18: 2063-74.
  • 10Shimizu T, Watanabe A, Ogawara M, Mori H, Shirasawa T. Isoaspartate formation and neurodegeneration in Alzheimer's disease. Arch Biochem Biophys 2000; 381: 225-34.

同被引文献9

引证文献1

中医临床研究
2011年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部