不稳定型心绞痛患者T淋巴细胞激活的研究

Study of T lymphocytes activation in unstable angina

目的：研究Ｔ淋巴细胞是否参与了不稳定型心绞痛（ＵＡ）相关的炎症反应。方法：空腹采肘静脉血，采用流式细胞分析仪分析１９ 例ＵＡ、２１ 例稳定型心绞痛（ＳＡ）患者和１６ 例健康者循环Ｔ淋巴细胞亚群和Ｔ细胞激活标志物ＣＤ２５和ＨＬＡ－ＤＲ抗原的表达，双抗体夹心ＥＬＩＳＡ法测定血清可溶性白细胞介素－２ 受体（ｓＩＬ－２Ｒ）。结果：ＵＡ患者ＨＬＡ－ＤＲ阳性的淋巴细胞数量和ｓＩＬ－２Ｒ水平显著高于ＳＡ患者和健康者。结论：ＵＡ患者循环Ｔ淋巴细胞被激活，免疫炎症反应参与了ＵＡ的发生。

Objective:To investigate whether circulating lymphocytes took part in the inflammatory reaction which related to unstable angina.Method:Nineteen patients with unstable angina,21 patients with unstable angina,and 16 healthy subjects were studied. The activating markers of T lymphocytes,CD 25 and HLA DR,were investigated by flow cytometric analysis. Soluble interleukin 2 receptor (sIL 2R) was measured in plasma by ELASA.Result:The results demonstrated that the number of HLA DR + lymphocytes and the level of sIL 2R in patients with unstable angina were higher (P< 0.01 ) than those in patients with stable angina and in control subjects.Conclusion:These results suggest that circulating T lymphocytes are activated in patients with unstable angina and immune system mediated inflammation may play an important role in the pathophysiology of unstable angina.