一氧化氮对透析低血压的影响

The Effect of Nitric Oxide on Hemodialysis induced Hypotension

目的：了解一氧化氮（ＮＯ） 对透析低血压的影响。方法：使用分光光度法测定伴或不伴透析低血压的血液透析（ＨＤ） 患者血浆中ＮＯ 的稳定代谢产物亚硝酸盐（ＮＯ－２ ） 和硝酸盐（ＮＯ－３ ）的水平。结果：透析低血压患者的平均动脉压（ＭＡＰ）显著低于血压正常的ＨＤ患者，前者ＮＯ－２ 和ＮＯ－３ 的血浆水平显著高于后者；低血压及血压正常的ＨＤ患者的ＭＡＰ 分别与其ＮＯ－２ 和ＮＯ－３ 的血浆水平呈负相关。结论：ＨＤ患者ＮＯ 产生增加，可能促使透析相关性低血压的发生。

Objective To investigate the effect of nitric oxide (NO) on intradialytic hypotension.Methods All patients were divided into two groups:intradialytic hypotension group (n=9) and normotensive group (n=10) during hemodialysis.The plasma nitrite (NO - 2) and nitrate (NO - 3) concentrations were assayed with spectrophoto metry in all patients.Results Mean arterial pressure (MAP) of intradialytic hypotension group was significantly lower than fhat of normotensive group.Meanwhile,the plasma levels of NO - 2/NO - 3 in the former (group) was significantly higher than that in the latter.There was a negative correlation between MAP and the concents of NO - 2/NO - 3 in both groups.Conclusion The increased concentration of NO during hemodialysis may contribute to the hemodialysis induced hypotension.