厄贝沙坦对老年人高血压左心室肥厚及舒张功能的影响

目的：观察厄贝沙坦对老年高血压左室肥厚（LVH）的影响。方法：78例患者口服厄贝沙坦150mg，每天一次，治疗32周，分别测量血压（SBP／DBP）以及彩色多普勒超声检测左室舒张末内径（LVDd）、左室舒张期室间隔厚度（IVST）、左室后壁厚度（LVPWT）、左室心肌重量指数（LVMI）、左室射血分数（LVEF）、二尖瓣口舒张早、晚期血流峰值速度E／A比值。结果：治疗后血压（SBP／I）BP）、LVDd、IVST、LVPwT、LVMI均明显下降，LVEF、E／A均明显上升。结论：厄贝沙坦不仅能有效降低老年人高血压和逆转其左心室肥厚，而且能明显改善其左心舒张功能。

Objective To observed the effects of irbesartan on left ventricular hypertrophy in elderly patients Methods 78 elderly patients with left ventricular hypertrophy were given irbesartan 150mg once daily for 32 weeks.Before and after 12 months treatment, left ventricular diastolic diameter（LVDd）,left ventricalar septal thick（IVST）, left ventricular posterior wall thick （LVPWT）, left ventricular ejection fraction（LVEF）, left ventricular mass index（LVMI） ,the ratio of peak flow velocity in early diastolic to that at atrial contraction（E/A） were measured by Doppler echocardiography. Results After 12 months treatment,blood pressure （SBP/DBP） ,LVDd ,IVST,LVPWT and LVMI were decreased significantly （P〈0.05）, LVEF,E/A were increased significantly （P 〈 0.05） Conclusion Nor only Irbesartan can decreased the hypertension and remodel the hypertrophied ventricle, but also improve left ventricular diastolic function.