氟罗沙星针剂原料的合成工艺

Synthesis technology of fleroxacin material for injection

目的：对注射用氟罗沙星原料的合成工艺进行探讨研究。方法：以６，７，８ － 三氟－１，４ － 二氢－４－ 氧喹啉－３－ 羧酸乙酯为原料，经４ 步反应得到氟罗沙星。结果：本品的元素分析、红外、质谱、核磁共振图谱数据与文献报道一致，总收率为５６－３％ ，产品经质量测定，完全符合注射用原料的标准。结论：采用该路线工艺生产的氟罗沙星原料产品符合注射用原料的标准，可直接用于注射剂的生产。

OBJECTIVE:To study the synthetic method and technology of fleroxacin material for injection.METHODS:This compound was synthesized using 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-ethylcarbonate as material.RESULTS:The element analysis,IR,MS and HNMR of synthetic product were comformable to literature,the total yield was 56.3%.The product was identified,its quality accords with injection′s demands.CONCLUSION:Fleroxacin material of this technology synthesized accords with injection′s demands,and it can be used for injection′s production.