交联聚维酮对对乙酰氨基酚片溶出度的影响

Crospovidone effects on the dissolution rate of paracetamol tablets

目的：研究崩解剂交联聚维酮对对乙酰氨酚片溶出度的影响。方法：采用交联聚维酮不同用量，不同加入方法，放置时间和再次加工。结果：交联聚维酮不同用量、不同加入方法对溶出度有显著影响，放置时间、和再次加工对溶出度无影响。结论：应用交联维酮应考虑其用量和加入方法。

OBJECTIVE:To study crospovidone effect on the dissolution rate of paracetamol tablets.METHODS:It is adopted the different content of crospovidone,the different manufactured way,the stored time,and made tablets again.RESULTS:It is effects significantly on the dissolution of paracetamol tablets by the different content of crospovidone and the different manufactured way,but is not significantly by the stored time and made tablets again.CONCLUSIONS:The content and manufactured way are considered when crospovidone is applied.