股骨头坏死的血液流变学实验研究

AN EXPERIMENTAL STUDY ON HEMORHEOLOGY OF AVASCULAR NECROSIS OF THE FEMORAL HEAD IN RABBITS

目的：探讨股骨头坏死的发病机理。方法：未成年雄性日本大耳白兔 ６０只，分成三组：Ａ组股骨头坏死组，共４０只，分为 ４小组。Ｂ组预防组，１０ 只。Ｃ组 创伤组，１０只。所有动物在术前及术后（Ａ，Ｂ两组动物分别术后２周，４周，８周，１２ 周，Ｃ组在术后２周，４周）抽耳缘静脉血作血液流变学检测。结果：Ａ组的血液粘度 较术前明显升高，与 Ｂ组同期比较，相差非常显著（Ｐ＜０．０１），Ｂ组血液粘度明显 低于Ａ组（Ｐ＜０．０１），与术前比较相差不显著（Ｐ＞０．０５），Ｃ组在术后２周内血液 粘度较术前升高，术后４周恢复到术前水平。结论：１．在兔股骨头坏死发病过程中， 血液维持高粘滞状态。２．肝素加山莨菪碱能明显改善血液高粘滞状态，预防实验 兔股骨头坏死的发生。３．在兔股骨头坏死早期，血液高粘滞状态出现在Ｘ线片异 常之前。血液流变学因素在股骨头坏死的发病机理中可能起重要作用。

To study the pathogenesis of avascular mecrosis of the femoral head . Method : 60 impubic male Japanese rabbits were divided into 3 groups: Group A(avascular necrosis of the femoral head) .40 rabbits were subdivided into 2w,4w,8w,12w subgroups according to execution time. Group B( preven-tion group) : 10 rabbits . Group C( control of trauma) : 10 rabbits. Hemorheological parameters were ex-amined preoperatively and 2w , 4w , 8w , 12w postoperatively before execution . Results : The blood viscosi-ty of group A increased significantly after operation . It was significantly higher than that of group B and C(P<0.01).No significance was found between blood viscosity of group B and that of preoperation( P > 0.05) .The blood viscosity of group C increased within 2 weeks postoperatively , and resumed to its preoperative level 4 weeks after operation . Conclusion : 1 . Hyperviscosity maintained in the course of avascular mecrosis of the femoral head in rabbits . 2 . Heparin and 654 - 2 could ameliorate hyperviscosi-ty , prevent avascular necrosis of the femoral head from occuring in rabbits . 3 . In the early stage of avas-cular necrosis of the femoral head in rabbita, hyperviscosity presented it self prior to abnormalities on ordinary X-ray films . Hemorheological factors probably played an important role in the pathogenesis of avascular necrosis of the femoral head .