新正天丸对偏头痛患者血液流变性和甲襞微循环的影响

EFFECT OF NEW ZHENGTIAN PILL ON NAIL FOLD MICROCIRCULATION AND HEMORHEOLOGY IN MIGRAJNEURS

目的：探讨偏头痛患者血液流变学，甲襞微循环的改变及新正天丸对其的影响。方法：偏头痛患者１００例，随机分为２组，观察组５０例，口服新正天丸对照组５０例，口服氟桂嗪，疗程均为３０天。并进行治疗前后血液流变学和甲襞微循环的检测。结果：观察组血液流变性各项指标中除红细胞压积变化不明显外，其它各项均有显著改善（Ｐ＜０．０５或Ｐ＜０．０１），而对照组中只有血小板聚集率和血沉改变明显（Ｐ＜０．０５），观察组对甲襞四项积分示明显改善（Ｐ＜０．０５或Ｐ＜０．０１），而对照组改善不明显（Ｐ＞０．０５）。结论：血液流变性及甲襞微循环的改变是偏头痛的重要病理特征，新正天丸对偏头痛血瘀障碍可能有改善作用。

Object:To investigate the changes of microcirculation nail fold and hemorheology in migrai-neurs during attacks and after New Zhengtian Pill(NZTP) therapy. Methods: A hundred patients with migraine were divided into two groups in random sampling. 50 treatment group patients were treated with 'NZTP' during two courses of treatment. 50 patients in control group were treated with 'Flunariz-ine' during two courses of treatments. The treatment courses of the two groups were 30d. Nailfold mi-crocirculation and hemorheology parameters were observed before and after treatment for curative effect. Results: All the indexs of blood rheology of the treatment group were evidently improved(P < 0.01 or P < 0.05) except for PCV. But only platelet agglutination rate and ESR were evidently improved (P < 0. 05) in the control group. The four nail fold microcirculation integrals of the treatment gorup were well improved( P<0.05orP<0.01), but those didn' t improve in the control group (P > 0.05). Conclu-sion : Abnormalities of nail fold microcirculation and hemorheology are important pathological features of migraine, and NZTP might change the block of microcirculation and hemorheology in the migraineurs.