摘要
目的：探讨高原肺水肿（ＨＡＰＥ）患者血液流变性、凝血及纤溶系统的 变化。方法：在海拔３７００ｍ对８例ＨＡＰＥ患者在治疗前和临床治愈后检测其血流变 指标、抗凝血酶 Ⅲ（ＡＴ－Ⅲ）及纤溶指标。结果：ＨＡＰＥ患者治疗前较临床治愈后全 血粘度、还原粘度、血浆粘度、血栓形成系数、红细胞聚集系数均显著升高（Ｐ＜０． ０５或０.００１）。血栓素Ｂ２、ｖＷＦ、纤维蛋白原、组织纤溶酶原激活剂及其抑制物活性， Ｄ－ｄｉｍｉｅｒ增高显著（Ｐ＜０．０５～０．００１），６－酮－前列腺素Ｆ、ＡＴ－Ⅲ降低非常显著 （Ｐ＜０．０１）。结论：血液粘度增高，Ｔ× Ｂ２与 ＰＧＩ２平衡失调，凝血及纤溶系统的功 能紊乱参与了ＨＡＰＥ的发病机理。
Objective: To investigate the changes of the hemorheology and coagulation-fibrinolytis sys-tem in patients with HAPE. Methods:Several indexs about hemorheological properties, AT-Ⅲ and fi-brinolytis system in 8 patients with HAPE were measured at altitude of 3700m, before and after treatment. Results: After teratment, the whole blood viscosity, plasma viscosity, and the index of throm-botic formation and RBC aggregation were significantly decreased (p<0.05 or 0.001); The TXB, vWF, Fg, t-PA, PAI and D-dimier were significantly decreasde also, while the activity of 6-Keto-PGF and AT-Ⅲ were significantly increased. Conculusions: The increased whole blood viscosity, the disorders between TXA2 and PGT2, coagulation and fibrinolysis system were contributed to the mechanism of HAPE.
出处
《中国血液流变学杂志》
CAS
1999年第4期239-242,共4页
Chinese Journal of Hemorheology
关键词
高原肺水肿
血液流变学
凝血
纤溶系统
high altutide pulmonary edema Hemorheological property Coagulation-fibrinolysis sy-sytem
