血浆置换患者TT病毒感染的观察

Observation of TTV infection in patients of plasma exchange

目的 研究血浆置换患者人群中经输血传播ＴＴ 病毒的感染状况及临床意义。方法用聚合酶链反应（ＰＣＲ） 方法检测４５ 例血浆置换患者和慢性肝炎患者的ＴＴ病毒（ＴＴＶ）感染情况，分析ＴＴＶ 感染的致病力。结果 ＴＴＶ 在４５ 例血浆置换患者中的感染率为１５ ．６ ％ （７／４５） ，在８７例慢性肝炎患者中的感染率３ ．４ ％ （３／８７） ，经统计学处理，两组感染率比较差异有显著性（χ２ ＝４ ．６０ ，Ｐ＜ ０ ．０５） 。７ 例ＴＴＶ 阳性患者中，６ 例有输血史。且ＴＴＶ 阳性和ＴＴＶ 阴性两组之间病死率差异无统计学意义。结论 输血、血浆在传播ＴＴＶ 感染有重要意义，ＴＴＶ 是否导致或促进重型肝炎肝衰竭的因素。

Objective To study the infection and clinical investigation of transfusion transmitted virus (TTV) in plasma exchange patients. Methods PCR was used in the detection of TTV infection in 45 cases of plasma exchange and 87 cases of chronic hepatitis and to evaluate its virulence. Results The positive rate of TTV were 15.6%(7/45) in 45 cases of plasma exchange and 3.4%(3/87) in 47 cases of chronic hepatitis. The difference between them was significant(χ 2= 4.60 , P <0.05). Of the seven TTV-positive patients, 6 had blood transfusion. There were no significant differences in the case fatality rate between TTV positive and TTV negative patients. Conclusion Results suggested that blood transfusion might be one of the critical routes to transmit TTV. But the role of making it the important cause of fulminant hepatitis needs further study.