格列吡嗪合并辛伐他汀对颈动脉粥样硬化斑块的疗效观察

Therapeutic Efficacy of Simvastatin plus Glipizide in Patients with Carotid Atherosclerotic Plaques

目的:研究辛伐他汀对治疗并发高脂血症的颈动脉粥样硬化斑块的影响,以及合用格列吡嗪对辛伐他汀的增效作用。方法:将高脂血症并发颈动脉粥样硬化患者108例,随机分为2组,辛伐他汀治疗组和格列吡嗪合并辛伐他汀治疗组,6个月治疗后,测量血脂生化指标、炎症因子活性和高频率彩色多普勒超声内-中膜厚度(IMT)。结果:两个治疗组,治疗后与治疗前相比,血脂指标,炎症因子指标及其IMT值都具有显著性差异(P<0.05)。与辛伐他汀单独治疗相比,格列吡嗪合并辛伐他汀治疗组的TC、TG和HDL-C没有显著性差异(P>0.05),但LDL-C显著减少(P<0.05),两组间ET-1和TNF-α以及IMT值差异显著(P<0.05)。结论:辛伐他汀能够改善血脂水平,降低炎症因子活性,进而对颈动脉粥硬化具有治疗作用,而合并格列吡嗪治疗能够起到增效作用。

To evaluate the therapeutic efficacy of simvastatin in patients with carotid atherosclerotic plaques complicated with hyperlipidemia,and the synergistic effect of glipizide. Methods： All the 108 patients were divided into two groups： group treatment with simvastatin and group treatment with simvastatin and glipizide. After treatment for 6 months, we measured the biochemical indicator of blood fat, included TC,TG,LDL-C and HDL-C ,the activity of inflammatory factors, included ET-1 and TNF-α , and the intima-media thickness （IMT）. Results： Both of the 2 groups, the scores of biochemical indicator of blood lipids, activity of inflammatory factors and intima-media thickness （IMT） were changed significantly after treatment （P〈0.05）. Compared with group treatment with simvastatin, the changes of the scores of TC,TG and HDL-C were not significant （P〉0.05）. However, the scores of LDL-C, activity of inflammatory factors and IMT were decreased significantly （P〈0.05）. Conclusion： Simvastatin could improve carotid atherosclerosis, through improving the level of blood lipids and reducing the activity of inflammatory factors, and glipizide had a synergistic effect.