眼针对脑缺血再灌注损伤大鼠血清BDNF含量的影响

The Effect of Eye Acupuncture Therapy on Serum BDNF Levels in Rats with Cerebral Ischemia-reperfusion in Jury

目的:观察眼针对脑缺血再灌注损伤大鼠血清脑源性神经营养因子(BDNF)含量的影响,探讨眼针对急性脑缺血再灌注损伤治疗的作用机制。方法:应用线栓法复制脑缺血再灌注损伤大鼠模型,采用眼针治疗,于再灌注后3、247、2 h进行神经功能缺损评分,采用ELISA方法测定大鼠血清BDNF含量的变化。结果:与模型组比较,眼针组大鼠神经功能缺损评分明显下降,大鼠血清BDNF含量增加(P<0.05)。结论:眼针具有明显改善大鼠脑缺血再灌注损伤的作用,其机制与提高机体血清BDNF含量有关。

Objective ： To investigate the effect of the eye acupuncture therapy on serum BDNF levels in rats with cerebral isehemia - reperfusion injury and the related mechanism. Methods： To establish the rat model of cerebral ischemia - reperfusion by suture method. The method of ELISA was taken to detect the change of the BDNF levels in rat serum after the eye acupuncture therapy. Results： Compared with the model group, the neurologic impairment score of the eye - acupuncture group decreased obviously; The levels of the BDNF in rat serum after the eye acupuncture therapy was strongly increased（ P 〈 0. 05）. Conclusion ： The eye acupuncture therapy can reduce cerebral ischemia - reperfusion injury evidently by increasing the levels of the serum cerebral isehemia- reperfusion in jury. evidently by increasing the levels of the serum BDNF.