帕瑞昔布对下肢手术后的镇痛研究

Clinical research on postoperative analgesia effect of parecoxib on legs

目的：评价帕瑞昔布对下肢手术术后镇痛的效果及安全性。方法：将87例患者随机分为两组。帕瑞昔布组：于术前30 min肌肉注射帕瑞昔布40 mg,间隔6~12 h重复1次,共2~4次,以后改为塞来昔布0.2 g,每日2次肌肉注射。镇痛泵对照组：芬太尼1.6 mg,氟哌利多5 mg,加生理盐水至100 mL,持续泵入,48 h后改为塞来昔布0.2 g,每日2次。采用盲法在不同时间评估患者术后镇痛效果,记录患者满意度及不良反应。结果：帕瑞昔布组的患者72 h满意度较高。两组间24 h内不同时间点的疼痛视觉模拟评分法（VAS）比较帕瑞昔布组患者评分较低。而随着时间的延长,两组间的差异无统计学意义。两组间患者的活动时疼痛评分无统计学意义。结论：帕瑞昔布对下肢手术患者的术后镇痛效果较好,患者满意度高,无明显不良反应。

Objective：To evaluate the postoperative analgesia efficacy and safety of parecoxib on legs.Methods：All selected cases who had operation on legs were divided into two groups at random.The 44 cases in the parecoxib group were administered with 40 mg parecoxib for injection twice a day.To repeat once every 6～12 h,a total of 2～4 times,than changed parecoxib to 0.2 g celecoxib 0.2 g,2 times in one day.The 43 patients in the control group were treated with 1.6 mg Fentanyl and 5 mg Droperidol,adding normal saline to the 100 mL,continuous infusion,after 48 hours it change to 0.2 g celecoxib,two times in one day.The demulcent efficacy of patients was evaluated at differents times.The satisfactory of patients and the side effect was recorded.Results：The satisfaction degree of the patients in postoperative 72 h in parecoxib group is higher.In this group,The VAS scales for pain at rest in a day after operation is lower.But the difference of the analgesia effect between two groups was not statistically significant after with time expand.The pain score of patients in activities between the two groups was not significally significant.Conclusion：The postoperative analgesia efficacy of parecoxib is better,and the patients are satisfied.parecoxib has fewer side effects.