^(13)C尿素呼气试验诊断小儿幽门螺杆菌感染的研究

Reliability of 13 C urea breath test in detection of Helicobacter pylori infections in children

目的 评估１３ Ｃ尿素呼气试验检测小儿幽门螺杆菌（Ｈｐ） 感染的可靠性。方法 ３７ 例具有上消化道症状的患儿行内镜检查，胃窦部粘膜活检，经快速尿素酶试验，组织学或Ｈｐ 培养，以决定是否感染Ｈｐ，并作１３ Ｃ尿素呼气试验。１３ Ｃ尿素呼气试验的敏感性、特异性、阳性预计值、阴性预计值是与内镜检测Ｈｐ 的结果比较计算得到的。结果 １３ Ｃ尿素呼气试验的敏感性为１００％ ，特异性为９６ ％ ，阳性预测值为９３％ ，阴性预测值为１００ ％ ，准确率为９７％ 。结论 １３ Ｃ尿素呼气试验有高度敏感性和特异性，对测定小儿Ｈｐ 感染是一种可靠的非侵入性的诊断方法。

Objective To assess the reliability of 13 C urea breath test ( 13 C UBT) in detection of Helicobacter pylori (Hp) infections in children Methods Gastroscopy, rapid urease test (RUT), Warthin Starry stain (W S stain), bacterial cultureas well as 13 C UBT were performed in 37 children with alimentary symptoms Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of 13 C UBT were calculated against gastroscopy Results The senstivity, spcificity, PPV and NPV were 100%, 96%, 93% and 100%, respectively Conclusion Non invasive 13 C UBT is highly sensitive, specific, and reliable method for detection of Hp infections in children