摘要
目的 探讨内源性一氧化碳(CO) 在新生儿缺氧缺血性脑病(HIE) 中的作用。方法 对28 例( 轻度组13 例,中度组10 例,重度组5 例)HIE 新生儿血浆CO 水平进行测定。结果 28 例HIE新生儿血浆CO水平为(2.15±0.20) mgL,高于正常对照组的(1.49 ±0.20) mgL,( P< 0.05)。血浆CO 水平的高低与病情严重程度密切相关,重度患儿CO 水平为(2.88±0.97) mgL,较轻、中度者为高[(1.70±0.87) mgL、(1.97±1.01) mgL],(P均< 0.05)。结论 CO可能作为一种内源性介质参与新生儿HIE的发病过程。
Objective To study the role of endogenous carbon monoxide (CO) in neonatal hypoxic ischemic encephalopathy (HIE) Methods The plasma CO levels were detected in newborn infants with HIE Results The plasma CO levels in 28 newborn infants with HIE were significantlty higher than those in the normal controls [(2 15±0 20) mg/L vs (1 49±0 20) mg/L ( P <0 05)] Moreover, the plasma CO levels were related to the severity of neonatal HIE The newborn infants with severe HIE had significantly higher CO levels [(2 88±0 97) mg/L] than those with the mild [(1 70±0 87) mg/L] and moderate HIE [(1 97±1 01) mg/L, P <0 05 respectively] Conclusion The present study suggests that CO as an endogenous mediator might take part in the pathogenesis of neonatal HIE
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1999年第8期499-500,共2页
Chinese Journal of Pediatrics
关键词
婴儿
新生
一氧化碳
脑缺氧
脑缺血
Infant,newborn
Carbon monoxide
Cerebral anoxia
Cerebral ischemia