成釉细胞瘤中Survivin的表达与影像学分型的关系

Expression of Survivin in Ameloblastoma and Correlation with Imaging Subtypes of Ameloblastoma

为探讨成釉细胞瘤中Survivin的表达和临床意义,以及Survivin的表S达与成釉细胞瘤影像学分型之间的关系。采用免疫组化S-P法检测60例成釉细胞瘤患者和22例正常人口腔粘膜中Survivin蛋白的表达,同时收集患者的手术前X线片并分型,结合Survivin蛋白在成釉细胞瘤中表达的结果进行分析。结果显示:60例成釉细胞瘤中Survivin的阳性表达率为71.67%(43/60),22例正常口腔粘膜中Survivin表达率为18.18%(4/22),二者间差异有统计学意义(P<0.05)。单房型成釉细胞瘤中Survivin的表达率为50%,较多房型(83.87%)和蜂窝型成釉细胞瘤(100%)低(P<0.01),多房型成釉细胞瘤和蜂窝型成釉细胞瘤中Survivin的表达率无差异(P>0.05)。由此可知,Survivin可能作为成釉细胞瘤诊断的一项重要指标;单房型成釉细胞瘤的凋亡抑制能力及细胞增殖能力较多房型和蜂窝型低。

To examine the expression of Survivin in ameloblastoma and the relationship between ameloblastoma and subtypes of ameloblastoma in imaging,the expression of survivin was examined by using the immunohistochemisty（SP） method.60 cases of ameloblastoma pre-operative X-ray film were collected.These specimens were divided into three groups.The relationship between the results of Survivin protein expression and imaging subtypes in ameloblastoma were analyzed.The expression of Survivin is 71.67%（43/60）in ameloblastoma samples and the expression of Survivin in normal oral tisues is 18.18%（4/22）.The expression of survivin in unilocular ameloblastoma is 50% and lower than multilocular ameloblastoma（83.87%）and honeycomb ameloblastoma（100%）（P0.01）.There was no statistically significant between multilocular ameloblastoma and honeycomb ameloblastoma（P0.05）.Survivin may be one of thre biomarker for early diagnose of ameloblastoma.The proliferation and apoptosis inhibiting capacity of multilocular ameloblastoma and honeycomb ameloblastoma may be higher than unilocular ameloblastoma.