胺碘酮与利多卡因对急性心肌梗死后室性心律失常QT间期改变的临床观察被引量：4

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摘要目的观察急性心肌梗死合并室性心律失常患者分别应用利多卡因与胺碘酮治疗前后心电图QT间期的改变,进一步分析两种药物的安全性。方法选择62例急性心肌梗死后合并室性心律失常患者,随机分为胺碘酮组(n=30)和利多卡因组(n=32),并进行观察。结果治疗3天时胺碘酮组QTc由用药前(396±17)ms延长至(398±16)ms,利多卡因组QTc由用药前(395±25)ms减至(394±26)ms,但两组用药前后QTc的差异无统计学意义(P>0.05)。治疗3天时胺碘酮组QTd由用药前(34±12)ms减至(21±9)ms,差异有统计学意义(P<0.05);利多卡因组QTd由用药前(32±11)ms减至(29±14)ms,但前后QTd的差异无统计学意义(P>0.05)。结论胺碘酮治疗急性心肌梗死并发室性心律失常较利多卡因更安全、有效,可作为首选药物。

作者畅君毅闫吉霞

机构地区河南省新乡市第二人民医院

出处《中国医学创新》 CAS 2011年第15期34-35,共2页 Medical Innovation of China

关键词胺碘酮利多卡因 QT间期

分类号 R541.7 [医药卫生—心血管疾病]

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