阿托伐他汀对急性心肌梗死患者血清高敏C反应蛋白的影响

Atorvastatin in patients with acute myocardial infarction in high sen-sitivity C reactive protein

目的观察阿托伐他汀对急性心肌梗死(AMI)患者血清高敏C-反应蛋白(hs-CRP)的影响,探讨阿托伐他汀在急性心肌梗死炎症反应中的作用。方法选取AMI患者65例,按发病前是否因心绞痛、血脂异常服用过阿托伐他汀分为两组。治疗组30例,服用阿托伐他汀(20 mg/d)5周;对照组35例,未服用阿托伐他汀。采用放射免疫法测两组患者血清hs-CRP水平。结果治疗组血浆hs-CRP水平低于对照组,差异有统计学意义(P<0.05)。结论阿托伐他汀可抑制炎症反应,稳定粥样斑块,缩小心肌梗死范围。

Objective To observe influence of atorvastatin treatment acute myocardial infarction hs - CRP, to explore atorvastatin in acute myocardial infarction inflammation in the role. Methods 65 cases of AMI patientsaecording to whether the result before the onset of angina, dyslipidemia atorvastatin were divided into two groups. The treatment group of 30 patients was take atorvastatin （20 mg/d） 5 weeks;the control group 35 cases was not take atorvastatin. Measured by radioim- munoassay 2 levels of serum hs - CRP levels. Results The levels of plasma hs - CRP than the control group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Atorvastatin inhibits inflammatory responses, plaque stability, reduces scope of myocardialinfaret.