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内源性和外源性雌激素对生长激素的影响

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摘要 人生长激素(GH)是由191个氨基酸组成的单肽链.它是由腺垂体细胞所分泌.正常情况下,生长激素呈脉冲式分泌,它的分泌受下丘脑产生的生长激素释放素(GHRH)的调节,还受性别、年龄和昼夜节律的影响,睡眠状态下分泌明显增加.GH能通过促进肝脏产生IGF-1,GH在介质间接促进生长期的骨骺软骨形成,促进骨及软骨的生长,从而使躯体增高.GH对中间代谢及能量代谢也有影响,可促进蛋白质合成,增强对钠、钾、钙、磷、硫等重要元素的摄取与利用,对胰岛素有拮抗作用,通过抑制糖的消耗,加速脂肪分解,使能量来源由糖代谢转向脂肪代谢.
作者 赵岫 张琴
出处 《中国医学创新》 CAS 2011年第15期192-194,共3页 Medical Innovation of China
基金 深圳市科技局计划项目 项目编号:200903099
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参考文献12

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