维生素E联合二甲双胍治疗非酒精性脂肪肝的临床研究

Clinical research of vitamin E joint metformin on treating nonalcoholic fatty liver disease

目的探讨维生素E联合二甲双胍治疗非酒精性脂肪肝的临床疗效。方法将112例非酒精性脂肪肝患者随机分为2组,即治疗组和对照组各56例。治疗组采用维生素E联合二甲双胍治疗,对照组单用二甲双胍治疗。6个月后观察两组患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷胺酰转肽酶(γ-GT)、胆固醇(CH)、甘油三酯(TG)、血尿酸(UA)的变化及治疗后临床疗效等情况。两组治疗期间均不用其他保肝降酶和降血脂类药物。结果 6个月后治疗组肝功能、血尿酸、血脂各项指标显著下降,治疗组与对照组比较,差异有统计学意义(P<0.05);治疗组、对照组总有效率分别为88.6%、53.3%,两组比较差异有统计学意义(P<0.05)。结论维生素E联合二甲双胍治疗非酒精性脂肪肝比单用二甲双胍疗效显著。

Objective To study the clinical curative effect on treatment nonalcoholic fatty liver disease with vitamin E joint mefformin. Methods 112 cases of nonalcoholic fatty liver disease patients were randomly divided into two groups： treatment group and control group, each 56 patients., the treatment group using vitamin E joint meffonnin and control group using mefformin alone. Six months later, observe two groups＇ alanine aminotransferase （ ALT ）, aspertate aminotransferase （ AST ）, γ- glutamy] transpeptidase （ γ- GT ）, cholesterol （ CH）, triglycerides （ TG）, and blood serum uric acid （ UA ）, the changes and the clinical＇ curative effect after treatment etc. During the two groups were no other liver and lipid - lowering drags Jiangmei. Resnits After six months, treatment group liver function, blood serum uric acid, lipid profile, each index dropped significantly. Comparing the treatment group with control group, the difference was statistically significant （ P 〈 0. 05 ）. The treatment group and control group total effectiveness rate was88.6% and 53.3%. respectively. Two groups of comparisons difference was statistically significant （ P 〈 0. 05 ）. Condusion Vitamin E combined with mefformin treatment of non - alcoholic fatty liver disease than single significant effect of metformin.