160 例小儿细菌性痢疾菌群分布药敏试验及临床意义

Study on the Bacterial Clump distribution, the Drug Sensitivity and the Clinical Significance in 160 Children with Bacterial Dysentery

目的 探索对细菌性痢疾最佳治疗方案。方法 将１６０ 例经细菌学证实的小儿急性菌痢分为１９８９～１９９３ 年和１９９４～１９９８ 年两个阶段，比较痢疾杆菌的菌群分布及药敏试验。结果 前后段均以福氏所占比例大，其次为宋氏，后段氯霉素敏感率较前段显著上升（ Ｐ＜ ００１），而庆大霉素、丁胺卡那、妥布霉素、氟哌酸则略有下降（ Ｐ＞ ００５），多重耐药性比较无明显差异（ Ｐ＞ ００５）。结论 ９０ 年代福氏痢疾杆菌已成为主要流行菌群，临床上应合理、交替选用敏感性高的药物。

Objective To make an approach on the most optimal scheme for the treatment of bacterial dysentery. Methods To compare the condition of bacterial clump distribution and drug sensitivity between two different stage-groups(the years 1989～1993 and 1994～1998) in 160 cases of bacterial dysentery via bacterialogical identification. Results B. shige Flexneri was found to be predominant in both two stage-groups, and B. Sonnei to be the next. The sensitivity rate of chloramphenicol in latter stage-group was significantly increased in comparison with that in the former group (P<0 01). The sensitivity rate of Gentamycin, Amikacin, Tobramycin and Norfloxacin were all somewhat decreased (P>0 05). There was no significant difference between two stage-groups for the comparison of multiple drug-tolerance (P>0 05). Conclustion In current 90s, B. Shige Flexneri is considered to be one of the main epidemic clump in various infections. High drug-sensitive drugs should be alternatively and rationally used in the clinical work. Particularly, Norfloxacin and its analogues are discovered to be the most ideal. [