摘要
目的:以明胶为囊材,优选黄芩苷微囊的制备工艺。方法:采用单凝聚法,以载药量为评价指标,利用均匀设计法优选微囊的最佳制备条件。结果:囊心囊材比为1∶2,温度45℃,转速550 r.min-1。结论:微囊制备工艺稳定、粒径分布及溶出符合要求。
Objective：To study the preparation method for baicalin microcapsule using gelatin gum as sealing materials.Method：Baicalin microcapsule was prepared by simple coacervation method.The uniform design was adopted to optimize the preparation procedure with drug loading as evaluation indexes.Result：The optimum preparation technique of baicalin microcapsule was：the ratio of core material to coating material was 1∶2;the temperature of encapsulation was at 45 ℃ and the stirring speed was 550 r·min-1.Conclusion：The results showed that baicalin microcapsule had appropriate diameter,distribution of microcapsule particles size and the dissolution meets the requirements.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第11期33-35,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
黑龙江省科技计划项目(QC04C19)
黑龙江中医药大学校基金项目(200719)
关键词
黄芩苷
微囊
单凝聚法
均匀设计
baicalin
microcapsule
simple coacervation
uniform design
