丹苘软胶囊对非酒精性脂肪肝模型大鼠的药效学研究

Effects of Danqing Soft Capsule on Rats with Non-alcoholic Fatty Liver Disease

目的:观察丹苘软胶囊对非酒精性脂肪肝(NAFLD)模型大鼠的药效学。方法:将实验动物随机分为正常组,模型组,丹苘软胶囊高、中、低剂量组,易善复组,采用高脂饲料建立SD大鼠非酒精性脂肪肝模型,丹苘软胶囊各组分别予相当于丹参石油醚浸膏0.4560,.228,0.114 g·kg-1 ig,易善复组每天予易善复0.159 g·kg-1 ig,正常对照组、模型组给药相同体积(1.2 mL·kg-1)的蒸馏水ig。ig 4周后,观察药物对大鼠血脂、肝脏脂肪含量及肝脏病理形态变化。结果:丹苘软胶囊各剂量组及易善复组血清TC,TG,LDL-C水平及肝脏TG,TC含量明显低于模型组(P<0.01,P<0.05);丹苘软胶囊各剂量组、易善复组肝细胞脂肪变性程度较模型组明显改善(P<0.01)。结论:丹苘软胶囊可以明显降低NAFLD模型大鼠血清TG,TC,LDL水平及肝脏TG,TC含量,改善肝组织病理形态。

Objective：To observe the effects of Danqing Soft Capsule（DSC） on rat with non-alcoholic fatty liver（NAFLD）.Method：The SD rats were randomly divided into control group,model group,DSC high dose group,medium dose group,low dose group,and polyene phosphatidyl choline（PPC） group.Non-alcoholic fatty liver disease model in SD rats was established with high fat diet.DSC high dose group,medium dose group and low dose group were intervened with different concentrations of DSC,which are respectively equivalent to petroleum ether extract of salvia 0.456,0.228,0.114 g·kg-1.PPC group was intervened with PPC of 0.159 g·kg-1ig.Control group and model group were administered the same volume（1.2 mL·kg-1,ig） of distilled water.After treatment for 4 weeks,rat liver pathological changes,TG,TC level,and blood lipids levels were observed.Result：The levels of TC,TG,LDL-C in serum and the levels of TG and TC in liver of control group,traditional Chinese medicine（TCM） groups and western medicine（WM） group were significantly lower than those of model group（P0.01,P0.05）.Compared with those in model group,the degrees of fatty degeneration of liver cells in TCM groups and WM group were significantly improved（P0.01）.Conclusion：DSC can reduce the level of TG,TC,LDL in serum as well as the level of TG and TC in liver.It can improve the steatosis of liver in rats with NAFLD.