定心胶囊对房颤大鼠血清D-二聚体的影响

Experimental Study on Effective Therapy of D-D for Dingxin Capsule to Rats of Atrial Fibrillation

目的:通过探讨定心胶囊对房颤大鼠血清D-二聚体含量的影响,揭示益气养阴活血中药预防和治疗房颤的作用机制。方法:选用体重在200～250 g的健康雄性Wistar大鼠,建立慢性房颤的动物模型。将造模成功的30只大鼠随机分为3组:模型组、定心胶囊治疗组(16.2 g·kg-1.d-1)和维拉帕米对照组(4.5 mg·kg-1.d-1),另设一组正常对照组。用药4周后,观察各组房颤大鼠血清D-二聚体的变化。结果:大鼠房颤模型组与正常对照组比较,血清D-二聚体的含量明显增加(P<0.05)。定心胶囊治疗组和维拉帕米对照组与模型组比较,可以明显地降低血清中D-二聚体的含量(P<0.05)。定心胶囊治疗组与维拉帕米对照组对房颤大鼠血清中D-二聚体的改善程度相比前者优于后者(P<0.05),有统计学意义。结论:定心胶囊能够明显降低房颤大鼠血清D-二聚体的水平,是防治房颤的有效药物。

Objective：The aim of this study is to develop the effective therapy on Dingxin capsule for D-dimer（D-D）of atrial fibrillation.To reveal the mechanism of Chinese medicine with the effects of nourishing Qi and Yin and activating blood in the prevention and treatment of Atrial Fibrillation（AF）.Method：Forty rats were randomized to 4 groups：normal group,model group,Dingxin capsule curatio group,verpamil intervention group.The level of D-D of AF rats were measured.Result：With the comparison of treating group and model group,the level of D-D in treating group lowed obviously（P0.05）.Both of them had statistic significance.Both Dingxin capsule group and Verpamil intervention group could low the level of D-D,but Dingxin capsule group is better.Conclusion：Dingxin capsule could correct the level of D-D in AF rats.D-D played important role in the pathogenesis of AF.