达英-35联合二甲双胍治疗38例多囊卵巢综合征

Effects of Diane-35 Combined with Metformin on Treatment of Polycystic Ovary Syndrome

目的:观察达英-35联合二甲双胍治疗多囊卵巢综合征(PCOS)的临床疗效。方法:38例临床患者,口服达英-35和二甲双胍3个周期,观察治疗前后临床症状、性激素水平、瘦素(Lp)、胰岛素抵抗指数(HOMA-IR)、性激素结合球蛋白(SHBG)、体重指数(BMI)和卵巢形态学等指标,比较生殖内分泌指标及糖代谢指标的变化。结果:用药后LH/FSH比值、雄激素水平、瘦素和胰岛素抵抗指数较治疗前均降低,性激素结合球蛋白较治疗前显著升高(P<0.01)。治疗后BMI下降(P<0.05),卵巢体积较治疗前明显缩小(P<0.05)。结论:达英-35联合二甲双胍可有效改善多囊卵巢综合征患者的胰岛素抵抗状态,降低血中雄激素水平并恢复生育功能,治疗多囊卵巢综合征安全有效。

Objective：To investigate the clinical effects of Diane-35 with metformin on treating women with polycystic ovary syndrome（PCOS）.Method：Thirty-eight patients took orally Diane-35 and metformin for 3 consecutive courses of treatment.Clinical symptoms,luteinizing hormone（LH）,follicle stimulating hormone（FSH）,T,Leptin,HOMA-IR,SHBG,BMI and the ovarian volume were kept under observation before and after taking Diane-35 and metformin.Reproductive hormones,serum glucose and insulin level were compared to that before therapy.Result：The content of LH/FSH,androgen,HOMA-IR were less than that before the treatmennt.The content of SHBG was more than that before taking medicine,and there were highly significant difference（P0.01）.The content of BMI was less than that before taking medicine,the size of ovaries was reduced and there were significant difference（P0.05）.Conclusion：Diane-35 and metformin are effective to reduce insulin resistance and androgen and to recover ovulation in women with PCOS.And the treatment was shown to be safe and effective.