缩氨基硫脲过渡金属配合物抗癌活性研究

Study of Antitumor Activities on Transition Metal Complexes of Thiosemicabazone

［目的］研究3－硝基苯乙酮缩氨基硫脲（HL）过渡金属配合物的抗癌活性。［方法］测试了配体和6个配合物对S180腹水癌细胞的体外抗癌活性及配合物Cu（L）2、Zn（L）2对S180腹水癌小鼠的生命延长作用和对S180实体瘤的抑制作用。［结果］配合物Cu（L）Cl、Cu（L）2、Zn（HL）2Cl2、Zn（L）2对S180腹水癌细胞有强的杀伤作用。配合物Cu（L）2、Zn（L）2剂量为10mg/kg时，对S180荷瘤小鼠的存活时间延长率分别为132．4％和55．2％，对S180实体瘤的抑癌率分别为81.59％和62.11％。［结论］配合物Cu（L）2是一种抗癌活性较好的物质。

[Purpose] To explore the antitumor activities of 3- mtroacetophenone - thiosemicarbazone (HL) transition metal complex.[Methods]The antitumor activities on S180 ascites cancer cell of the ligand and 6 complexes were evaluated in vitro. Prolonged survival time and solidtumor growth - inhibition of tumor- bearing S180 mice of the complexes Cu(L)2, Zn(L)2 were evaluated. [Results] The complexes Cu(L) Cl, Cu(L)2, Zn(HL)2Cl2, Zn(L)2 exhibited high antitumor activities on S180 ascites cancer cell. Prolonged survival time of tumor - bearing mice was132.4% ana 55.2% respectively and inhibitory rate of S180 solid tumor was 81. 59% ana 62. 11% respectively, when a dose of 10mg/kg ofcomplexes Cu(L)2, and 10mg/kg of complexes Zn(L)2 were given. [Coclusion]Complex Cu (L)2 is the matter of better antitumor activity thanothers.