白细胞介素6和维甲酸对肝癌细胞细胞周期动力学的影响

Effects of Interleukin 6 and Retinoic acid on cell cycle of Line of Hepatocellular Carcinoma Cells

为探讨重组白细胞介素6（IL-6）和全反式维甲酸（RA）诱导肝癌细胞凋亡的作用，用流式细胞仪测定IL－6和RA对HdeG2肝癌细胞的细胞周期动力学和凋亡诱导率的影响。结果表明IL－6和RA作用于细胞周期的S期，抑制肝癌细胞的DNA合成。IL－6诱发细胞凋亡率显著高于RA的作用，此效应与其作用时间和剂量有关。提示IL－6可促进体外培养的肝癌细胞凋亡，抑制其DNA合成。但需进一步探讨IL-6治疗肝癌的可能性及其价值。

To investigate whether intereden 6 and retinoc acid(RA) will induce apoptosis of hepatocellular carcinoma (HCC) cells,effects of IL - 6 and RA on cell cycle and apoptosis induction rate of HCC cells were observed by flow cytometry assays. The results showed that both IL- 6 and RA might act on S phase and inhibit DNA Synthesis of HCC cells. The apoptosis rate induced by IL - 6 was higher than that by RA. It suggests that IL - 6 could induce apoptosis of HCC cells. It is necessary to study the therapeutic value of IL - 6 on HCC further.