生长抑素与血管加压素治疗食管静脉曲张出血多中心对照研究

Clinital study on Somatostatin and Vasopessin in tratment of esophageal varices bleeding

本文用生长抑素8肽（奥曲肽）、生长抑素14肽（舒得定）、三甘氨酰赖氨酸加压素（可利新）和氨戊酸血管加压素（必压生）等4种进口药物与国产垂体后叶素在食管静脉曲张破裂出血的止血效果、再出血率、并发症、病死率和副反应诸方面进行多中心对照观察。可利新和必压生在3小时和6小时完全止血率略高于另2种生长抑素。但12小时和24小时完全止血率则相似（P＞0．05）。与垂体后叶素相比止血效果明显（p＜0．05）。输血量及副反应亦明显减少。但再出血和存活率方面各组间无明显差别。

The purpose of this study was to investigate the effects of Somatostation (Octreotide, Somatosin) and Vasopressin (Pitressin, Glypressin) in treatment of esophageal varices bleeding(EBB). The rate of complete hemostasis of Pitressin and Glypressin in 3h and 6h was quicker than that Octreotide and Somatosin respectively. But effects of 4kinds of drugs in 12h and 24h were similar (p>0.05). The emergent hemostatic rate was higher than that of Pituitrin(p<0.05). The volume of blood transfusion was obviously less than that of Pituitrin. They can not prolong survival duration of patients.