2007-2010年医院鲍曼不动杆菌感染的耐药分析

Antimicrobial resistance analyses of Acintobacter baumannii isolated in hospital from 2007 to 2010

目的了解医院鲍曼不动杆菌感染的分布及耐药情况。方法分析鲍曼不动杆菌菌株的标本来源和临床分布情况，用最低抑菌浓度（minimal inhibitory concentration，MIC）法结合纸片扩散法（K—B法）检测其对抗菌药物的敏感性。结果2007--2010年共分离鲍曼不动杆菌62株，其中53株（占85．5％）分离自痰标本，21株（占33．9％）分离自重症监护室（intensive care units，ICU）。62例患者中54．8％（34例）的患者患有严重的肺部感染疾病。分离菌对头孢哌酮／舒巴坦的耐药率为20．0％、敏感率为73．3％，对其他抗菌药物的耐药率超过60．0％。泛耐药菌占33．9％（21株），其中52．4％（11株）的泛耐药鲍曼不动杆菌感染发生在ICU病房。结论鲍曼不动杆菌的耐药率较高，且呈多重耐药趋势。加强菌株的耐药性监测，以药敏结果指导临床用药有助于减少耐药菌株的出现。

Objective To investigate the prevalence and antimicrobial resistance of Acinetobacter baumannii in nosocomial infection. Methods Clinical features and the origin of A. baumannii samples were analyzed retrospectively. The minimal inhibitory concentration （MIC） and Kriby-Bauer diffusion test （K-B） were used to determine the susceptibility to the antimicrobial agents. Results A total of 62 strains of A. bauman- nii were isolated from 2007 to 2010. Fifty-three strains（ 85.5% ） of specimens were separated from respiratory tract. The isolation rate ofA. baumannii was the highest in intensive care units （ICU） （21 strains, 33.9% ）. 54.8% （34/62） of patients suffered from severe lung infection. The resistance rate of cefoperazon/sulbactam was 20.0%, and the susceptible rate was 73.3%. The resistance rate to other antimicrobial agents is above 60.0%. The prevalence of muhi-drug resistance of A. baumannii was about 33.9%, and 52.4% of this kind of A. baumannii were occured in ICU. Conclusion The infection of A. baumannii is more and more severe and tends to be resistant to multiple-drug and pan-drugs. The susceptible testing should be conducted to help the clinic to decrease the resistance rate.