异丙酚复合芬太尼维持麻醉对脑代谢的影响

Effect of propofol-fentaynl intravenous anesthesia on cerebal metabolism

观察异丙酚复合芬太尼维持麻醉对脑代谢的影响。方法： 择期手术病人８ 例， 芬太尼、硫贲妥钠、维库溴铵诱导插管， 静脉联接Ｇｒａｓｅｂｙ 微泵异丙酚８ ｍｇ／ （ｋｇ·ｈ） ， 芬太尼１ μｇ／ （ｋｇ·ｈ）维持麻醉。连续监测ＭＡＰ、心电图、脉搏氧饱和度和呼气末二氧化碳分压， 同步采集动脉血和颈内静脉血作血气分析， 计算动－ 静脉氧含量差（Ｄａ － ｖＯ２） 和脑氧摄取率（ＥＲＯ２） 。结果： 异丙酚麻醉维持平稳， Ｄａ － ｖＯ２ 和ＥＲＯ２ 在给药３０ ｍｉｎ 、６０ ｍｉｎ 较气管插管后５ ｍｉｎ 无明显改变， 有平均动脉压下降和心动过缓。结论： 异丙酚复合芬太尼维持麻醉可保持脑氧供需平衡稳定。

Objective:To evaluate the influence of propofol fentaynl intravenous anesthesia(IVA) on cerebal metabolism.Methods:The anesethesia was induced by fentaynl thiopentone vecuronium and maintained by propofol fentaynl vecuronium in 8 patients during ordinary surgery.Arterial and venous blood samples were drainaged simultaneously through radial artery and internal jugular catheterization.The cerebal arteriovenous differences of oxygen content (Da-vO 2)were measured,and the extracting rate of oxyen(ERO 2)was calculated.Results:There were no significant differences in Da-vO 2 and ERO 2 between the incubation after 5 min and in 30,60 min after anesthesia maintained with propofol fentaynl.Conclusion:IVA with propofol fentaynl can keep the balance of cerebal oxygen.