高压氧加纳洛酮治疗弥漫性轴索损伤

High-pressure Oxygen and Naloxone in Treatment of Diffuse Axonal Injury

目的:总结高压氧加纳洛酮联合治疗对弥漫性轴索损伤患者促醒作用及对预后的影响。方法:将56例DAI患者(GCS<8分)随机分成2组。治疗组28例,在常规治疗的基础上应用高压氧加纳洛酮治疗,对照组28例,即在常规治疗加高压氧治疗,不使用纳洛酮治疗。2组于伤后3个月作格拉斯哥治疗结果分级(GOS)评分评估预后,同时比较2组患者的清醒时间。结果:高压氧加纳洛酮治疗组恢复良好率(39.3%)高于对照组(17.9%)(P<0.05)。结论:高压氧加纳洛酮治疗弥漫性轴索损伤患者时缩短昏迷时间,明显提高患者的生存质量。

Objective：To study the agryphnotic effect of high-pressure oxygen with Naloxone in treatment of diffuse axonal injury and its prognosis.Methods：56 patients（GCS8 分）of diffuse axonal injury were randomly assigned into 2 groups.The control group was treated with mutine measures and high-pressure oxygen,which involved 28 patients,and the other group was treated with high-pressure oxygen and Naloxone based on the routine measures,which there were 28 patients.GOS after 3 months and consciousness recovery rate were compared.Results：Recoverv rate of treatment groups（39.3%）was better than that of the control（17.9）（p0.05）.Conclusion：High-pressure oxygen and Naloxone can improve the recovery of coma in patients with diffuse.axonal injury and life quality are highly achieved.