摘要
目的:观察甲钴胺对糖尿病(DM)大鼠神经保护作用,探讨其可能的作用机制。方法:专选取60只健康Wistar大鼠,正常对照组(NG)20只,其余40只以链脲佐菌素(STZ)腹腔注射建立糖尿病大鼠模型。将DM大鼠随机分为糖尿病对照组(3M)20只,糖尿病甲钴胺治疗组(DMC)20只。2组控制血糖方法相同,8周后2组分别给予生理盐水、甲钴胺(1OOug/kg)隔日臀大肌肌注1次,连续4周,观察其坐骨神经传导速度(SNCV、MNCV)、cAMP、cGMP含量的影响及病理改变。结果:甲钴胺治疗组大鼠神经病变坐骨神经的传导速度明显提高,坐骨神经cAMP、cGMP含量明显增加。结论:甲钴胺对糖尿病大鼠神经功能有明显保护作用。
Objective：To research the effects of Mecobalamin injection on function and structure of sciatic nerve in diabetic rats.Methods：Included were 3 groups of Wistar rats：normal control（11=20）,Mecobalam Injection treated diabetic rats（n=20）and dietic rats without Mecobalamin injection treatment（n=20）.Diabetic rats were treated with 100ug/kg mecobalamin injection,then after 4 weeks of treatment,the nerve conduction velocity and the cAMP and cGMP amount in the nerve were measured.Results：Mecobalamin iniection was able to decreased blood and plasma viscosity,improvenerve conduction velocity and the cAMP and cGMP amount in the nerve of mecobalamin treament group were increased significantly（P0.01）.Conclusion：Mecobalamin injection improves the functionhave in treatment of diabetic peripheral neuropathy in DPN rats.
出处
《中国伤残医学》
2011年第5期28-30,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
甲钴胺
糖尿病大鼠
神经病变
Mecobalamin injection
Diabetes rats
Neuropathy
