摘要
目的:以罗布麻为模型药物,研制基于扩散、溶胀、渗透压机制的定时脉冲片,并考察其体外释药特性。方法:通过体外释放度试验,考察片芯崩解剂种类与用量、渗透压活性物质种类与用量、包衣液的组成与厚度等处方因素对脉冲片体外释放的影响。结果:脉冲片由含有罗布麻干浸膏的片芯及外包2层衣膜构成,内层为溶胀层,由HPMC E5构成;外层为控释层,由Eudragit RS 100,RL 100的混合物构成。该制剂在体外释放时滞为(5±0.5)h。结论:罗布麻脉冲片在体外具有脉冲释放特性。
Objective：Using Apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion,swelling,osmotic pressure mechanism and to evaluate the release characteristics.Method：The pulsatile release tablets were prepared by film coating methods using HPMC E5 and Eudragit.The effect of formulation on pulsatile release of A.venetum was investigated.Result：The pulsed-release tablet was prepared by a swelling layer coating which contains HPMC E5 and a controlled-release membrane containning Eudragit.The delayed release time of the tablets was（5.0±0.5） h.Conclusion：The pulsatile release characteristics of A.venetum pulsatile release tablets were confirmed in vitro.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第11期1427-1430,共4页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09310-005)
关键词
脉冲片剂
罗布麻
制备工艺
释药特性
pulsatile tablets
Apocynum venetum
tablet
preparation
characterization of release
