金属卟啉分子印迹聚合物的合成与性能研究

Synthesis and properties of molecularly imprinted polymers for metalloporphyrins

以5-(4-羟基苯基)-10,15,20-三苯基卟啉锌为印迹分子,4-乙烯基吡啶为功能单体,乙二醇二甲基丙烯酸酯为交联剂,合成了具有金属卟啉识别能力的分子印迹聚合物.紫外可见滴定光谱研究表明,功能单体与印迹分子在聚合前形成1:1的配合物.通过吸附试验、荧光光谱及斯卡查特分析法,考察了分子印迹聚合物对锌卟啉化合物的识别性能.结果表明,印迹聚合物对结构类似的卟啉化合物具有良好的识别能力,对印迹分子荧光性能的影响远大于其对应的非印迹聚合物.在浓度较低时,印迹聚合物对印迹分子的结合常数和最大结合量分别为:1.61×106L/mol和3.22×10-5mol/g.

A novel kind of molecularly imprinted polymer to the template of 5-（4-hydroxyphenyl）-10,15,20-triphenylporphinatozinc（Ⅱ）was prepared by using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker.The interaction between 4-vinlypyridine and the template as well as three other zinc porphyrin analogs was quantitatively investigated with UV-vis titration spectroscopy,and the binding constants were calculated accordingly.Batch rebinding and fluorescence spectrum measurements were applied to characterize the recognition properties of obtained polymers.It was found that the molecularly imprinted polymer showed specific affinity to the template molecule in comparison with other zinc porphyrin analogs.Scatchard analysis on the molecularly imprinted polymer was performed.The association constant and the maximum number of binding sites were estimated to be 1.61×10^6 L/mol and 3.22×10^-5 mol/g,respectively.