布渣叶抗内毒素和急性毒性实验研究

Anti-endotoxic Effects and Acute Toxic Experiment of Folium microcotis

目的:研究布渣叶的抗内毒素作用和急性毒性。方法:采用内毒素致小鼠休克死亡法观察布渣叶的抗内毒素作用。通过对小鼠空腹ig给药,观察小鼠出现的毒性反应,测定半数致死剂量(LD50)。结果:23.4、11.7g.kg-1剂量下布渣叶能显著提高内毒素血症小鼠生存率(P<0.05),LD50=91.76g(生药).kg-1,相当于成人日用量的214倍。结论:布渣叶具有较好的抗内毒素作用,在临床常规剂量下使用是安全、毒性极小的。

OBJECTIVE：To study the anti-endotoxic effects and acute toxic experiment of Folium microcotis.METHODS：The anti-endotoxic effect of F.microcotis was observed by endotoxin-induced the death in mice.The toxic reaction was observed in mice through intragastric administration and the median lethal doses（LD50） were determined.RESULTS：The different doses of F.microcotis（23.4 g·kg-1,11.7 g·kg-1） could improve the survival rate of endotoxemia mice significantly（P0.05）.The LD50 of F.microcotis was 91.76 g·kg-1,which was as much as 214 times of adult normal dose.CONCLUSION：F.microcotis has obvious anti-endotoxic effects with mild toxicity and is safe by oral administration.