白藜芦醇对大强度运动大鼠肾脏功能的保护作用

Protective Effects of Resveratrol on Kidney in Intensive Exercise Rats

目的:探讨白藜芦醇对大强度运动后大鼠肾脏功能的保护作用。方法:将24只两月龄SD大鼠随机分为安静对照组、运动组、运动+白藜芦醇组,每组8只,运动组在活动跑台上进行大强度跑台训练。实验持续8周后,测试肾脏各项指标。结果:大强度运动可造成大鼠肾脏中MDA、总NOSi、NOS、NO显著升高,总SOD、CuZn-SOD、GSH-Px、cNOS、Na+K+-ATPase、Ca2+-ATPase显著下降。补充白藜芦醇可使大鼠运动后肾脏中MDA、总NOSi、NOS、NO下降,总SOD、CuZn-SOD、Mn-SOD、GSH-Px、cNOS、Na+,K+-ATPase、Ca2+-ATPase水平升高。结论:白藜芦醇可增强肾脏的抗氧化能力,保持肾脏酶活性。提示白藜芦醇对大强度运动后肾脏功能有良好保护作用。

Objective： To examine the protective effects of resveratrol on kidney in intensive exercise rats.Method： Twenty-four 2-month old SD mice were selected and divided into control group,exercise group,and exercise＋resveratrol group randomly.There were eight mice in each group.Mice of exercise group were trained on intensive treadmill for eight weeks.Followings indicators of kidney were detected.Results： Levels of renal MDA,total NOS,iNOS,NO increased significantly in rats after intensive exercise;while those of total SOD,CuZn-SOD,GSH-Px,cNOS,Na＋K＋-ATPase,Ca2＋-ATPase decreased significantly in rats after intensive exercise.The supplement of resveratrol degraded levels of renal MDA,total NOS,iNOS,NO after intensive exercise;while raised those of total SOD,CuZn-SOD,GSH-Px,cNOS,Na＋,K＋-ATPase,Ca2＋-ATPase after intensive exercise.Conclusion： The study demonstrated that resveratrol could enhance renal antioxygen and enzymatic activity which suggested the protective effects of resveratrol on renal function in intensive exercise rats.