Th9与支气管哮喘

Th9 and bronchial asthma

支气管哮喘（简称哮喘）是一种由多种细胞如淋巴细胞、嗜酸粒细胞、肥大细胞等及其细胞组分参与的气道慢性炎症疾患，Th2细胞被认为是哮喘发病机制中的主要效应细胞。长期以来，白介素9（IL-9）都被认为是Th2类细胞凶子，在变应性疾病，尤其是过敏性哮喘、变应性鼻炎等发病机制中起着重要的作用。近年来研究发现，机体内可能存在着一群新型的不同于目前已知Thl、Th2及Thl7等效应细胞，被称之为“Th9”细胞。Th9细胞在转化生长因子β及L-4联合刺激下分化而来，具有分泌IL-9和IL-10的能力。Th9细胞作为效应性T细胞，在促进组织炎症发生的过程中起着重要作用。现就Th9细胞的生物学功能及与哮喘的关系进行简要综述。

Bronchial asthma （asthma） is a kind of chronic air way inflammatory diseases mediated asthma. Recent data identified a novel subset of T cells generated in presence of TGF -β and IL 4 that produces both IL 9 and IL-10, named ＂Th9＂ cell. Th9 cells do not express any well defined transcription factors like T-bet, GATA3, RORyt, emphasizing that Th9 cells are different from Thi, Th2 and Th17 populations. Th9 cells act as effector T cells and promote more severe and unusual tissue inflammation. The aim of this review is to combine data from human and animal models of allergic diseases, and propose how Th9 cells function in asthma.