左氧氟沙星和质子泵抑制剂三联疗法治疗抗幽门螺杆菌失败时补救治疗的疗效观察

目的系统性评价左氧氟沙星和质子泵抑制剂(PPI)三联疗法治疗幽门螺杆菌(HP)的疗效和不良反应发生率。方法将收治的84例幽门螺杆菌感染抗HP失败患者随随机分成治疗组和对照组,各42例,对照组进行常规四联疗法补救治疗,治疗组进行左氧氟沙星和PPI三联疗法补救治疗观察、对比两组患者疗效。结果对照组根除率85.7%,疗组根除率95.2%,两组比较差异无统计学意义(P>0.05),对照组不良发生率14.3%,治疗组不良反应发生率9.5%,两组差异无统计学意义(P>0.05)。结论左氧氟沙星和PPI三联疗法治疗抗HP失败患者能够提高HP根除率、降低不良反应发生率。

Objective To systematically assess the effectiveness and adverse reaction rates of levofloxacin PPI triple therapy in the treatment of Helicobacter pylori（HP）.Methods 84 cases of failure of Helicobacter pylori infection in patients with anti-HP were randomly divided into treatment group and control group accepted in our hospital,of which is 42 cases,the control group used quadruple chemotherapy remedy treatment,the treatment group was given levofloxacin and PPI triple therapy,the effectiveness of the two groups were observed and compared.Results Eradication rate of control group was 85.7%,treatment group was 95.2%,no significant difference between the two groups（P 0.05）.the incidence rate of adverse of control group was 14.3%,treatment group was 9.5%,there was no statistical difference between two groups（P 0.05）.Conclusion Levofloxacin and PPI triple therapy used for patients who failed anti-HP can improve HP eradication rate and reduce the incidence rateof adverse reflection And can be used as the first clinical anti HP treatment options.