替米沙坦对早期高脂喂养OLETF大鼠代谢综合征相关因素的影响

Effect of Telmisartan on metabolic syndrome correlation factor of OLETF rats fed with high-fat diet

目的观察替米沙坦对早期高脂喂养自发性2型糖尿病(T2DM)OLETF大鼠代谢综合征相关因素的影响。方法 OLETF大鼠48只,根据OGTT 2 h血糖和体重随机分为5组:替米沙坦组(L)、替米沙坦联合二甲双胍组(LM)、吡格列酮组(P)、二甲双胍组(M)和高脂对照组(O)。LETO大鼠12只,为非糖尿病对照组(NC)。22周龄对未发生T2DM大鼠实施药物干预。48周龄观察代谢综合征相关指标:T2DM发病率、FFA、血脂及体重变化。结果 L组糖尿病发病率与O组比较有下降趋势,但差异无显著性(P=0.085)。LM组糖尿病发病率与O组比较差异有显著性(P=0.035);FFA、TC、TG、LDL均低于O组,差异有显著性(P分别为0.040、0.023、0.037和0.000)。P组体重高于其他各组,差异有显著性(P<0.05)。结论替米沙坦联合二甲双胍能够降低高脂喂养OLETF大鼠T2DM发病率,并调节FFA及血脂水平且不增加OLETF大鼠体重,从而改善代谢综合征状况。

【Objective】 To investigate the effect of Telmisartan on metabolic syndrome correlation factor in OLETF rats fed with high-fat diet.【Methods】 According to OGTT 2 h and body weight,forty-eight OLETF rats were randomly divided into five groups： Telmisartan（group L）,combination of Telmisartan and Metformin（group LM）,Pioglitazone（group P）,Metformin（group M） and high-fat diet（group O）.Twelve LETO rats fed with normal diet served as normal control group（group NC）.At forty-eight weeks,morbidity of diabetes,FFA,serum lipids and body weight were observed after twenty-two weeks treated drugs.【Results】 Compared with group O,T2DM was decreased but no statistical significance（P =0.085）.T2DM in group LM was significantly lower than group O（P =0.035）;Compared with group O,the FFA,TC,TG,LDL were markedly decreased（P =0.040,0.023,0.037 and 0.000,respectively）.The body weight of group P was higher than that of rats in other groups（P 0.05）.【Conclusion】 Combination of Telmisartan and Metformin can prevent the morbidity of diabetes of OLETF rats fed with high-fat diet and improve FFA,serum lipid disorders,and the body weight keep stable.