K-ras及PTEN在45岁以下妇女子宫内膜癌中的表达

Expression of K-ras and PTEN in endometrial carcinoma under 45-year-old younger women

目的探讨K-ras及PTEN在45岁以下妇女子宫内膜癌组织中的表达及相关性。方法选取因子宫病变行子宫全切的标本66例,其中子宫内膜腺癌42例、子宫内膜非典型增生6例、正常子宫内膜18例。采用免疫组织化学SP法测定K-ras及PTEN在45岁及以下妇女子宫内膜组织中的表达。结果①K-ras在子宫内膜不典型增生及子宫内膜癌中的表达明显高于正常子宫内膜,差异有显著性(P<0.05);PTEN在正常子宫内膜中、子宫内膜不典型增生和子宫内膜癌中的表达逐渐降低,表达缺失率分别为16.67%、66.67%和85.71%,差异有极显著性(P<0.005)。②K-ras及PTEN在子宫内膜癌中的表达与临床分期、组织学分级、肌层浸润深度及有无淋巴转移无关。③在子宫内膜癌中K-ras与PTEN表达无显著性(rs值=0.187,P>0.05)。K-ras阳性表达与PTEN阳性表达不一致。结论 K-ras及PTEN的异常表达发生在年轻妇女子宫内膜癌的早期,与预后无关。

【Objective】 To study the expressions and relationship among K-ras and PTEN in endometrial carcinoma under 45 of age.【Methods】 Selected 66 cases uterine specimens which were excised for uterine diseases,including 42 cases of endometrial carcinoma,6 cases of atypical endometrial hyperplasia and 18 cases of normal endometrium.The expression of K-ras and PTEN in the tissues of endometrium was detected by the immunohistochemical method.【Results】 The expression of K-ras in atypical endometrial hyperplasia and endometrial carcinoma is much higher than that in normal endometrium（P 0.05）.Compared with normal endometrium（16.67%）,the negative rates of PTEN in atypical endometrial hyperplasia（66.67%） and endometrial carcinoma（85.71%） increased significantly（P 0.005）.The expression of K-ras and PTEN has very little do to with clinical stages,histological grades,myometrial invasion depth and lymphatic metastasis.In endometrial carcinoma group,there was no correlation between the expressions of K-ras and PTEN（rs=0.187,P 0.05）.The positive expression of K-ras had inconsistency with PTEN.【Conclusions】 These results suggest that the abnormal expression of K-ras and PTEN might be a valuable index for the diagnosis of endometrial carcinoma in the early stage for the patients under 45 years old.