龙眼果核化学成分的研究

Chemical constituents from fruits of Dimocarpus longan

目的研究龙眼Dimocarpus longan果核的化学成分。方法采用硅胶柱色谱、聚酰胺柱色谱以及葡聚糖凝胶色谱等手段对龙眼果核95%乙醇提取物进行分离,并利用理化性质和光谱数据鉴定化合物的结构。结果从龙眼果核的95%乙醇提取物中分离得到12个化合物,分别鉴定为β-谷甾醇(1)、苯乙醇(2)、2-甲基-1,10-十一烷二醇(3)、(24R)-6β-羟基-24-乙基-胆固醇-4-烯-3-酮(4)、齐墩果酸(5)、松脂醇(6)、烟酸(7)、对羟基苯甲酸(8)、β-胡萝卜苷(9)、1-O-甲基-D-肌-肌醇(10)、尿嘧啶(11)、腺嘌呤核苷(12)。结论化合物2～8和10为首次从龙眼果核分得,其中化合物3是新化合物,命名为龙眼二醇(longandiol)。

Objective To investigate the chemical constituents of the fruits of Dimocarpus longan. Methods The chemical constituents were isolated from 95% alcohol-extract on seeds of longan by silica gel, polyamide, as well as Sephadex LH-20 column chromatography..Their structures were identified on the basis of physical and chemical properties and spectral analysis. Results Twelve compounds were isolated and identified as： β-sitosterol （1）, 2-phenylethanol （2）, 2-methyl-1,10-undecanediol （3） （24R）- 6β-hydroxy-24-ethyl-cholest-4-en-3-one （4）, oleanolic acid （5）, pinoresinol （6）, nicotinic acid （7）, 4-hydroxybenzoic acid （8）, β-daucosterol （9）, 1-O-methyl-D-myo-inositol （10）, uracil （11）, and adenosine （12）. Conclusion Compounds 2-8 and 10 are reported from the pericarp of longan （the fruits ofD. longan） for the first time, and compound 3 is a new compound named longandiol.