醒脑清眩胶囊的降压作用研究

Antihypertensive Study of Xingnao Qingxuan Recipe

目的：观察醒脑清眩胶囊的降压作用及其对眩晕的影响。方法：①测正常麻醉猫１次ｉｄ和清醒ＳＨＲ多次ｉｇ给药的降压作用；②以氯仿引起的眼球震颤的潜伏期和持续时间评定药对眩晕的影响；③测定药物对正常和痉挛状态下的脑基底动脉的作用。结果：①１次ｉｄ醒脑清眩胶囊２．８ｇ·ｋｇ－１明显降低猫血压；每天１次，连续１４ｄｉｇ生药１．４，２．８，５．６ｇ·ｋｇ－１使ＳＨＲ的血压明显下降；②１次ｉｇ２．８，５．６ｇ·ｋｇ－１，连续３次，使氯仿引起的眼球震颤的潜伏期延长１４．４％和１３．０％，眼球震颤的持续时间缩短３３．３％和２３．３％；③醒脑清眩胶囊明显舒张由ＫＣｌ和５ＨＴ引起的狗脑基底动脉痉挛，测得其ＩＣ５０分别为０．３３８（０．１～３．０ｍｇ·ｍｌ－１的抑制率在１８．０％～９７．３％）和０．４７５ｍｇ·ｍｌ－１（０．１～３．２ｍｇ·ｍｌ－１的抑制率在１２．９％～９３％）。结论：醒脑清眩胶囊有明显的降压和抗眩晕作用，这些作用与扩张脑血管，包括扩张基底动脉有关。

Objective:To observe the effect of decreasing blood pressure of Xingnao Qingxuan Casuples.Method:The blood pressure in normal and anesthetied cats was examined with direct method,the blood pressure in the conscious SHR was obtained by indirect method.Results:Duodenuos administration(id)of XQC of 2.8g/kg produced a decrease of blood pressure in normal cats;XQC of 1.4,2.8 and 5.6g/kg once a day for 14 days proouced a dose dependent reduction of blood pressue in SHR,3～4 days after administration the blood pressure returned to the level before but the change was not significant.With gastric administration of XQC of 2.8 and 5.6g/kg for 3 times,the incubation period of eyeball tremor induced by chloroform by dropping into the ear was prolonged by 14.4% and 13.0%,and the keeping time shortened by about 33.3% and 23.3%respectively.Brain basic arterial spasm induced by KCl or 5 HT in dog was relaxed obviously by XQC in vitro experiment.Conclusion:XQC has the effect of reducing blood pressure resisting dizziness,which is related to the diastole of brain blood vessel.