国内人附红细胞体病64例文献分析

Analysis of literature on 64 cases of human eperythrozoonosis in China

目的借鉴Meta分析原理,调研有关人附红细胞体病的文献,分析其规律。方法检索中国期刊全文数据库（1994-2010年）获得目标文献,建立文献评价表。结果符合要求的文献共44篇,收集人附红细胞体病病例64例,其中男患者与低龄患者较多;临床表现复杂多样,以发热、贫血、乏力出现最多;实验室检查RBC与Hb多下降,WBC与PLT多正常,ALT多升高,TBIL多正常;有效药物以氨基糖苷类和四环素类应用较多,其中分别以庆大霉素和强力霉素居首。结论人附红细胞体病的临床表现和实验检查等具有多样性和复杂性特点,探讨相关规律对于减少该病的漏诊和误诊至关重要。

Objective To analyze and determine rules governing domestic cases of human eperythrozoonosis over the past 16 years in accordance with evidence-based medicine.Methods Literature in the China Journal Full-text Database（1994-2010） was reviewed and then an evaluation table was established.Results More patients were male than female and many were very young.Clinical manifestations varied and were most often fever,anemia,and fatigue.RBC and Hb decreased in most patients,WBC,PLT,and TBIL were mostly normal,and ALT mainly increased.The most widely effective drugs were aminoglycosides and tetracyclines,including gentamicin and doxycycline.Conclusion Human eperythrozoonosis resulted in complex and varied clinical manifestations and laboratory.Rules governing human eperythrozoonosis must be studied in order to decrease misdiagnoses and missed diagnoses.