中药封脐疗法治疗慢性荨麻疹的临床观察及对T细胞亚群的影响

Clinical Study on Treatment of Chronic Urticaria and effect on T-lymopholyte subsynecology with the application to navel in the treatment

目的:探讨中药封脐疗法对慢性荨麻疹(CU)临床近期、远期疗效,以及对患者细胞免疫功能的影响。方法:对照组口服氯雷他定分散片(原研),治疗组加用中药封脐,观察疗效和治疗前后外周血T淋巴细胞亚群、外周血EOS计数和血清嗜酸性阳离子蛋白(ECP)的变化。结果:治疗后,治疗组CD4+升高、CD8+下降,CD4+/CD8+比值升高,ECP计数下降。治疗后6个月随访,治疗组复发率明显低于对照组。结论:中药封脐疗法可增强慢性荨麻疹患者细胞免疫功能,提高疗效,减少复发。

Objective： To observe the immunity and clinical therapeutic effect of Chronic Urticaria with external application to navel in the treatment.Methods： 65 patients were divided into two groups at random.The treatment group were treated with external application to navel,the control group took Loratadine Dispersible Tablets.The EOS count,the T-lymopholyte subsynecology,the ECP and the function of liver and kidney were detected and compared before and after treated.The clinical therapeutic effect and the recurrence rate were compared as well.Results：After the treatment,there were significant differences about the ECP count（P0.05）.It is also found that the higher difference about CD4 percentand CD4/CD8 rations（P0.05）.The rate of recurrence in the treatment group is lower than the other.Conclusion： The external application to navel in the treatment can adjust the imbalance of Th1/Th2 rations,regulate anaphylaxis and allergy,reduce the rate of recurrence and enhance immunity function.