肝炎治疗药物对肝炎患者鼻黏膜改变的影响

Effect of Hepatitis Drugs on Nasal Mucosa of the Patients with Hepatitis

目的探讨治疗肝炎的药物对肝炎患者鼻黏膜改变的影响。方法选择2008年6月～2010年6月入院治疗的慢性乙型肝炎患者50例,经系统的基础治疗后比较患者治疗前后鼻黏膜的改变情况,并记录治疗后血小板、白细胞、血红蛋白的变化情况。结果治疗后的鼻黏膜比治疗前明显改变,鼻出血、鼻黏膜糜烂、嗅觉减退的患者比治疗前明显增加(P<0.05),且血小板、白细胞、血红蛋白与治疗前比较也明显降低,差异有统计学意义。结论治疗肝炎的药物可引起患者血小板、白细胞、血红蛋白减少,并可导致患者鼻黏膜不同程度受损,故临床上在治疗慢性乙型肝炎时应注意加用保护患者血象及保护鼻黏膜的药物,降低肝炎患者并发症的发生率。

Objective To explore effect of hepatitis drugs on nasal mucosa of the patients with hepatitis. Methods 50 patients with chronic hepatitis B from 2008 July to 2010 July were accepted basis treatment. Compared nasal mucosa change of patients before and after treatment. Recorded PLT, WBC and Hb of patients before and after treatment. Results After the treatment, the number of Nose bleeding, nasal mucosa erosion and smell decline were more than before. After the treatment, PLT, WBC and Hb of patients has fallen. There were a significant difference between before and after treatment （P〈 0.05 ）. Conclusion Hepatitis drugs can make PLT, WBC and Hb of patients decline, causing nasal mucosa of patients injury. So on the treatment of chronic hepatitis, protecting nasal mucosa of patients, increasing of blood and lower the incidence of complications are more important.