苯巴比妥与地西泮联合治疗小儿热性惊厥疗效分析

Curative Effect Analysis on Combination of Phenobarbital and Diazepam in the Treatment of Children Febrile Convulsion

目的探讨地西泮与苯巴比妥联合治疗小儿热性惊厥的临床疗效。方法选取我院2005年1月～2009年12月收治的78例热性惊厥患儿,随机分为单用组和联合组各39例,单用组单用苯巴比妥控制惊厥,联合组用苯巴比妥与地西泮联合治疗。治疗后比较两组的药物起效时间、复发人数和并发症发生情况。结果治疗后两组患儿的起效时间和复发人数比较差异有统计学意义(P<0.05);两组并发症比较差异无统计学意义(P>0.05)。结论苯巴比妥与地西泮联合治疗小儿热性惊厥起效快、复发率低,值得临床医生在治疗小儿热性惊厥时借鉴应用。

Objective Curative effect analysis on combination of phenobarbital and diazepam in the treatment of children febrile convulsion. Methods Select 78 children with febrile convulsion from Januray 2005 to December 2009, randomly divided into Single group and joint group, treat single group with phenobarbital, joint group with combination of phenobarbital and diazepam. Compare onset time of drug, number of recurrence, and complications after treatment. Results Differences of onset time of drug, number of recurrence shows statistical significance （P 〈 0.05 ）; no statistical significance for complications （F 〉 0.05 ）. Conclusion Combination of phenobarbital and diazepam is a therapy with rapid onset and low recurrence rate in treatment of children febrile convulsion, and is worth clinical application.