甘精胰岛素联合格列喹酮治疗糖尿病肾病的临床评价

Therapeutic Effect of Insulin Glargine Combined with Gliquidone for the Treatment of Patients with Diabetic Nephropathy

目的观察糖尿病肾病患者采用甘精胰岛素联合格列喹酮治疗的临床效果及安全性。方法 58例糖尿病肾病患者随机分为对照组及治疗组,对照组采用胰岛素治疗,治疗组采用格列喹酮加甘精胰岛素联合治疗,比较两组患者治疗效果、肾功能及低血糖发生率。结果两组患者治疗后FBG、2hBG、HbA1c、UAER水平均降低,对照组与治疗组间无显著差异。两组患者治疗前BUN、SCr水平无明显变化。治疗组低血糖发生率低于对照组。结论甘精胰岛素联合格列喹酮治疗糖尿病肾病可有效控制血糖,安全性和依从性较单独使用胰岛素治疗好。

Objective To observe the efficacy and safety of insulin glargine combined with Gliquidone in patients with diabetic nephropathy. Methods Fifty eight patients with diabetic nephropathy were randomly divided into control group and treatment group; Patients in the treatment groups were treated by insulin glargine injection combined with Gliquidone and patients in the control group were treated by premixed insulin injection twice daily. Therapeutic efficacy, renal function and incidence of hypoglycemia were contrasted. Results After treatment, the levels of FBG, 2hBG, HbAlc and UAER in two groups all decreased obviously, but there were no statistically significant differences between the two groups. The levels of BUN, SCr had no marked difference after the experiment. Patients in the treatment group had fewer hypoglycemic episodes than those in the control group. Conclusion Insulin glargine combined with Gliquidone can control the blood glucose effectively in patients with diabetic nephropatby and has high safety accompanied by a simple and easy way in application.