喉癌术后手术部位感染情况调查及危险因素分析

Study on surgical site infection following laryngectomy and its risk factors

目的探讨喉癌术后手术部位感染(SSI)及其发生的危险因素。方法回顾性调查我院2006年1月至2010年12月96例喉癌手术患者的临床资料,应用SPSS 13.0软件分析其发病相关因素。结果 96例喉癌患者发生SSI 15例,感染率为15.6%;单因素分析表明:临床分期、手术时间、术式及术前气管切开是SSI发生的危险因素(P<0.05);Logistic逐步回归分析表明:临床分期(OR=0.273)和全喉术式(OR=8.085)是喉癌术后SSI的独立危险因素。结论对临床分期较晚、手术范围较大的患者,应注意提高术中手术技巧、缩短手术时间、正确及时处理术后感染,以减少SSI的发生,降低咽瘘的发生率。

Objective To investigate the infection at surgical sites of laryngectomy and the related risk factors.Methods We retrospectively analyzed the clinical data of 96 laryngeal cancer patients,who received laryngectomy in our hospital between Jan.2006 and Dec.2010.SPSS 13.0 software was used to analyze the risk factors.Results We found that 15 patients（15.6%） had infection in the surgical sites.ANOVA analysis indicated that the clinical stage,operation time,surgical procedures and preoperative tracheostomy were the risk factors for surgical site infection（P0.05）.Logistic stepwise regression analysis indicated that the clinical stage（OR=0.273） and surgical procedures（OR=8.085） were the independent risk factors.Conclusion Improving the surgical techniques,shortening operation time,and timely and correct management of infection can reduce surgical site infection and pharyngo-cutaneous fistula in laryngeal cancer patients at advanced clinical stages and with extensive operation involvement.