CD_(44)v3基因蛋白在恶性卵巢肿瘤中的表达及其临床意义

Clinical Significance of Expression of CD_(44)v3 Protein in Malignant Ovarian Tumors

目的 :探讨CD4 4v3基因在卵巢恶性肿瘤组织中的表达情况及其临床意义。方法 :用免疫组织化学S -P法 ,检测 41例恶性卵巢肿瘤、2 0例良性卵巢肿瘤和 2 1例正常卵巢组织中CD4 4v3基因蛋白的表达情况并分析相关的临床病理因素。结果 :1)CD4 4v3表达阳性率恶性组显著高于良性组和正常组 ;2 )有转移者CD4 4v3阳性率显著高于无转移者 ,转移灶阳性率高于原发灶 ;CD4 4v3阳性表达者近期疗效比阴性者差 ;3)CD4 4v3阳性表达率与临床期别有一定关系 ,但与病理类型、组织学级别无关。结论 :1)CD4 4v3与肿瘤的发生、发展相关 ;2 )CD4 4v3与卵巢恶性肿瘤的浸润和转移相关 ,可以作为预测肿瘤转移潜能指标 ;3)CD4 4v3与近期疗效有关 ,可作为评估预后的指标。

Objective: To study the clinical significance of expression of CD 44 v3 in malignant ovarian tumors. Methods: Immunohistochemical stain was used to determined the expressions of CD 44 v3 in biopsy specimen of 41 malignant ovarian tumors, 20 benign ovarian tumors and 21 normal control. Results: 1) The positive rates of CD 44 v3 in malignancies were significantly higher than those in benign tumors and control group. 2) The positive expression rate of CD 44 v3 in residual focus >2cm was significantly higher than that of the residual focus smaller or equal to 2cm. 3) The positive expression rate of CD 44 v3 in metastatic lesion was significantly higher than that in primary focus, and the primary focus with metastasis was markedly higher than that without metastasis. 4) The short-term curative effect of patients with positive expression of CD 44 v3 was significantly lower than that of negative patient. 5) No close correlation was observed between the positive expression of CD 44 v3 and pathological grade in cancer tissue. Conclusion: 1) CD 44 v3 is correlated with the carcinogenesis and progression of tumor. 2) CD 44 v3 is correlated with the metastasis of malignant ovarian tumor and it may be used for predicting the metastasis of cancer. 3) CD 44 v3 is associated with the curative effect so it would be a new marker for evaluating the prognosis of the disease.